From 1960-1968, Sister Mary Corita used the building as her studio and classroom where she made some of her most recognizable works, hosted creative leaders, and influenced a generation of young artists. Sister Corita's studio, at 5518 Franklin Avenue, is the only extant property of primary significance associated with Sister Corita's art production in Los Angeles. 

Known as the "Pop Art Nun," Sister Corita became a cultural figure known around the world. Throughout the 1960s Sister Corita used Pop Art to raise awareness about social injustices that included poverty, racism, women's rights, and the Vietnam War.