The Lloyd Wright Studio-Residence was designed by noted architect Lloyd Wright, son of Frank Lloyd Wright, as his personal studio and residence.

Lloyd Wright opened his own practice in Los Angeles in 1916; he also supervised construction of some of his father's projects, including Hollyhock House. The younger Wright's design for his home and studio incorporates patterned concrete blocks similar to those of his father's "textile block" houses, on which Lloyd collaborated. 

This particular concrete block pattern features an interlocking design of stylized Joshua trees. Located on a compact corner lot, the studio contains a large workroom opening to an enclosed patio on the ground floor. The studio served as a laboratory for Lloyd's design ideas as well as a showcase of his work for potential clients.

The building underwent an extensive restoration in the 1990s, supervised by Lloyd Wright's son, Eric Lloyd Wright. A new foundation was constructed, and some blocks that had deteriorated over time were repaired or replaced.

The Conservancy holds a conservation easement that protects the studio's exterior, as well as a statue located on the patio.