Otomisan Japanese Restaurant located 2506½ East First Street is housed in a rare 1920s streetcar commercial building along East First Street in the Boyle Heights neighborhood of Los Angeles. 

Built by Ryohei Nishiyama, the single-story commercial building originally housed a Japanese-operated grocery store, and later included a Japanese-operated florist shop and barber shop. In the 1950s, the grocery store was converted to a food establishment and initially housed a confectionary and later a Japanese restaurant.

The property achieved Historic-Cultural Monument listing in January 2022.